Web Articles Directory Tonga: September 2012

Wednesday, 26 September 2012

Sennosides Granules

Pronunciation: SEN-oh-sides
Generic Name: Sennosides
Brand Name: Senokot

Sennosides Granules are used for:

Treating constipation.

Sennosides Granules are a stimulant laxative. It works by irritating bowel tissues, resulting in bowel movements.

Do NOT use Sennosides Granules if:

you are allergic to any ingredient in Sennosides Granules

you have had recent abdominal surgery or require immediate abdominal surgery

you have appendicitis; bleeding of the stomach, intestine, or rectum; or an obstruction in your intestines (fecal impaction)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Sennosides Granules:

Some medical conditions may interact with Sennosides Granules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have congestive heart failure, you are experiencing nausea or vomiting, or you have undiagnosed stomach pain

Some MEDICINES MAY INTERACT with Sennosides Granules. However, no specific interactions with Sennosides Granules are known at this time.

Ask your health care provider if Sennosides Granules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Sennosides Granules:

Use Sennosides Granules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Sennosides Granules by mouth with or without food.

Take Sennosides Granules with a full glass of water (8 oz/240 mL). Drinking extra fluids while you are taking Sennosides Granules are recommended. Check with your doctor for instructions.

It is best to take Sennosides Granules at bedtime.

If you miss a dose of Sennosides Granules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Sennosides Granules.

Important safety information:

A bowel movement usually occurs in 6 to 12 hours.

Do not use for longer than 1 week without checking with your doctor.

Using Sennosides Granules for a long time may result in loss of normal bowel function.

Do not take additional laxatives or stool softeners with Sennosides Granules unless directed by your doctor.

If you notice a sudden change in bowel habits that lasts for 2 weeks or more, stop using Sennosides Granules and check with your doctor.

Sennosides Granules may discolor the urine pink to red, or yellow to brown.

Sennosides Granules should not be used in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Sennosides Granules while you are pregnant. It is not known if Sennosides Granules are found in breast milk. If you are or will be breast-feeding while you use Sennosides Granules, check with your doctor. Discuss any possible risks to your baby.

Overuse of laxatives can lead to a DEPENDENCE on laxatives to have a bowel movement. In severe overuse cases, some laxatives have caused damage to the intestines and bowel.

Possible side effects of Sennosides Granules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abdominal discomfort or cramping; diarrhea; nausea.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); kidney inflammation; poor bowel function; rectal bleeding.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Sennosides side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center ( http://www.aapcc.org), or emergency room immediately.

Proper storage of Sennosides Granules:

Store Sennosides Granules at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Keep Sennosides Granules out of the reach of children and away from pets.

General information:

If you have any questions about Sennosides Granules, please talk with your doctor, pharmacist, or other health care provider.

Sennosides Granules are to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Sennosides Granules. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

More Sennosides resources

Sennosides Side Effects (in more detail)
Sennosides Use in Pregnancy & Breastfeeding
Drug Images
Sennosides Drug Interactions
Sennosides Support Group
6 Reviews for Sennosides - Add your own review/rating

Compare Sennosides with other medications

Bowel Preparation
Constipation

Saturday, 22 September 2012

Aqueous Iodine Oral Solution BP

1. Name Of The Medicinal Product

Aqueous Iodine Oral Solution BP

2. Qualitative And Quantitative Composition

Iodine BP 5.0% w/v

Potassium Iodide BP 10.0% w/v

3. Pharmaceutical Form

Oral Solution

4. Clinical Particulars

4.1 Therapeutic Indications

For use in the pre-operative management of hyperthyroidism.

4.2 Posology And Method Of Administration

Oral.

Dose: adults, children and the elderly: 0.1 – 0.3ml well diluted in milk or water.

Dosage schedule: to be taken three times a day for six days.

4.3 Contraindications

Contraindicated for patients hypersensitive to iodine or iodides, and use in pregnancy and lactation.

4.4 Special Warnings And Precautions For Use

Should not be used for long term treatment.

Dispensing pack-not for retail sale.

Keep all medicines away from children.

Use with caution in children.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

Administration of this product may interfere with tests of thyroid function.

4.6 Pregnancy And Lactation

Not to be used during pregnancy and lactation. Iodides cross the placenta and are excreted in breast milk. There is a possibility of goitre in infants of mothers taking iodides.

4.7 Effects On Ability To Drive And Use Machines

None known.

4.8 Undesirable Effects

May cause allergic reactions, including urticaria, angioedema, cutaneous haemorrhage or purpuras, fever, arthralgia, lymphadenopathy and eosinophilia, coryza-like symptoms, headache, lachrymation, conjunctivitis, laryngitis, bronchitis, and pain in the salivary glands. In addition to the above, use may lead to adverse effects on the mouth such as metallic taste, increased salivation, burning or pain. Swelling and inflammation of the throat, acneform skin disorders, depression, insomnia, impotence and diarrhoea (which may be bloody) can also result.

4.9 Overdose

Symptoms of acute poisoning from ingestion of iodine include a disagreeable metallic taste, vomiting, abdominal pain and diarrhoea may occur. Renal failure may occur 1-3 days later. Death may be caused by circulatory failure, swelling of the epiglottis causing asphyxia, aspiration, pneumonia or pulmonary oedema. Oesophageal stricture may occur if the patient survives the acute stage. The fatal dose of iodine is 2 to 3g. Symptomatic treatment for allergic reactions and iodism may be required, although symptoms usually subside rapidly when administration of iodine or iodide is stopped. In acute poisoning copious draughts of milk and starch mucilage should be given. If there is no oesophageal damage the stomach may be emptied by aspiration and lavage with dilute starch mucilage or a 1% solution of sodium thiosulphate. Use of gastric lavage with activated charcoal has also been suggested. Electrolyte and water losses should be replaced and the circulation should be maintained. Pethidine or morphine sulphate may be given for pain, under medical supervision. A tracheotomy may become necessary.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

Iodine and iodides are used in the pre-operative treatment of hyperthyroidism in conjunction with antithyroid agents. The patient is rendered euthyroid with an antithyroid agent and iodine or iodides are added to the therapy before subtotal thyroidectomy. Iodine aqueous solution is given to render the thyroid firm and avoid the increased vascularity and friability with increased risk of haemorrhage that may result from the use of an antithyroid agent alone.

5.2 Pharmacokinetic Properties

Iodine is converted to iodide, which is trapped in the thyroid gland.

Iodides are excreted mainly in the urine with smaller amounts excreted in the faeces, sweat and saliva. They cross the placenta and are excreted in breast milk.

5.3 Preclinical Safety Data

No data of relevance which is additional to that included on other sections of the SPC.

6. Pharmaceutical Particulars

6.1 List Of Excipients

Purified water BP

6.2 Incompatibilities

None known.

6.3 Shelf Life

100ml: 36 months unopened.

500ml: 36 months unopened.

6.4 Special Precautions For Storage

Store below 25°C.

6.5 Nature And Contents Of Container

100ml: amber glass bottle, plastic cap.

500ml: amber glass bottle, plastic cap.

6.6 Special Precautions For Disposal And Other Handling

None

7. Marketing Authorisation Holder

Thornton & Ross Ltd.,

Linthwaite Laboratories

Huddersfield

HD7 5QH

8. Marketing Authorisation Number(S)

PL 00240/6170R

9. Date Of First Authorisation/Renewal Of The Authorisation

04.12.98

10. Date Of Revision Of The Text

12.11.01

11 DOSIMETRY (IF APPLICABLE)

Not Applicable

12 INSTRUCTIONS FOR PREPARATION OF RADIOPHARMACEUTICALS (IF APPLICABLE)

Not Applicable

Friday, 21 September 2012

levofloxacin Ophthalmic

lee-voe-FLOX-a-sin

Commonly used brand name(s)

In the U.S.

Iquix

Quixin

Available Dosage Forms:

Solution

Therapeutic Class: Antibiotic

Chemical Class: Fluoroquinolone

Uses For levofloxacin

Ophthalmic levofloxacin is used in the eye to treat bacterial infections of the eye. Ophthalmic levofloxacin works by killing bacteria.

levofloxacin is available only with your doctor's prescription.

Before Using levofloxacin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For levofloxacin, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to levofloxacin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Use is not recommended in infants under 1 year of age. In children older than 1 year, levofloxacin is not expected to cause different side effects or problems than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of levofloxacin in the elderly with use in other age groups, levofloxacin is not expected to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking levofloxacin, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using levofloxacin with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Cisapride

Dronedarone

Mesoridazine

Pimozide

Sparfloxacin

Thioridazine

Using levofloxacin with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acarbose

Acecainide

Acetohexamide

Alfuzosin

Amiodarone

Amitriptyline

Amoxapine

Apomorphine

Arsenic Trioxide

Asenapine

Astemizole

Azimilide

Azithromycin

Benfluorex

Bretylium

Chloroquine

Chlorpromazine

Chlorpropamide

Ciprofloxacin

Citalopram

Clarithromycin

Clomipramine

Clozapine

Crizotinib

Dasatinib

Desipramine

Disopyramide

Dofetilide

Dolasetron

Droperidol

Erythromycin

Flecainide

Fluconazole

Gatifloxacin

Gemifloxacin

Gliclazide

Glimepiride

Glipizide

Gliquidone

Glyburide

Granisetron

Guar Gum

Halofantrine

Haloperidol

Ibutilide

Iloperidone

Imipramine

Insulin

Insulin Aspart, Recombinant

Insulin Glulisine

Insulin Lispro, Recombinant

Lapatinib

Lopinavir

Lumefantrine

Mefloquine

Metformin

Methadone

Miglitol

Moricizine

Moxifloxacin

Nilotinib

Norfloxacin

Nortriptyline

Octreotide

Ofloxacin

Paliperidone

Pazopanib

Perflutren Lipid Microsphere

Perphenazine

Posaconazole

Procainamide

Prochlorperazine

Promethazine

Propafenone

Protriptyline

Quetiapine

Quinidine

Quinine

Ranolazine

Salmeterol

Saquinavir

Sematilide

Sodium Phosphate

Sodium Phosphate, Dibasic

Sodium Phosphate, Monobasic

Solifenacin

Sorafenib

Sotalol

Sunitinib

Tedisamil

Telavancin

Telithromycin

Terfenadine

Tetrabenazine

Theophylline

Tolazamide

Tolbutamide

Toremifene

Trazodone

Trifluoperazine

Trimipramine

Troglitazone

Vandetanib

Vardenafil

Vemurafenib

Voriconazole

Warfarin

Ziprasidone

Using levofloxacin with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Betamethasone

Corticotropin

Cortisone

Cosyntropin

Deflazacort

Dexamethasone

Fludrocortisone

Fluocortolone

Hydrocortisone

Methylprednisolone

Paramethasone

Prednisolone

Prednisone

Triamcinolone

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of levofloxacin

Dosing

The dose of levofloxacin will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of levofloxacin. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

To use levofloxacin ophthalmic solution (eye drops):

First, wash your hands. Then tilt the head back and pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close the eyes. Do not blink. Keep the eyes closed for 1 or 2 minutes to allow the medicine to come into contact with the infection.

If you think you did not get the drop of medicine into your eyes properly, use another drop.

To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface (including the eye). Also, keep the container tightly closed.

For ophthalmic solution dosage form:
- For bacterial conjunctivitis:
  - Adults and children 1 year of age and older—Days 1 and 2: Put one to two drops in the affected eye(s) every two hours while awake. Do not put drops in more than 8 times a day. Days 3 through 7: Put one to two drops in the affected eye(s) every 4 hours while awake. Do not put drops in more than 4 times a day.
  - Infants and children up to 1 year of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of levofloxacin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using levofloxacin

If your eye infection does not improve within a few days, or if it becomes worse, check with your doctor.

levofloxacin may cause your eyes to become more sensitive to light than they are normally. Wearing sunglasses and avoiding too much exposure to bright light may help lessen the discomfort.

levofloxacin Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

voice changes

body aches or pain

congestion

dryness or soreness of throat

runny nose

swelling of the eyelid

tender, swollen glands in neck

trouble in swallowing

Itching, pain, redness or swelling of eye or eyelid

watering of eyes

decreased vision

fever

feeling of having something in the eye

headache

hoarseness

eye burning, dryness, itching, or pain

increased sensitivity of eyes to light

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More levofloxacin Ophthalmic resources

Levofloxacin Ophthalmic Use in Pregnancy & Breastfeeding
Levofloxacin Ophthalmic Support Group
0 Reviews for Levofloxacin Ophthalmic - Add your own review/rating

levofloxacin ophthalmic Concise Consumer Information (Cerner Multum)

Iquix Drops MedFacts Consumer Leaflet (Wolters Kluwer)

Iquix Prescribing Information (FDA)

Quixin Prescribing Information (FDA)

Quixin eent Monograph (AHFS DI)

Quixin Eye Drops MedFacts Consumer Leaflet (Wolters Kluwer)

Compare levofloxacin Ophthalmic with other medications

Conjunctivitis, Bacterial
Ophthalmic Surgery

Ventricular Fibrillation Medications

Definition of Ventricular Fibrillation:

A disorganised chaotic contraction of the ventricle that fails to effectively eject blood from the ventricle.

During ventricular fibrillation the patient is unconscious and will die if emergency intervention is not undertaken

Drugs associated with Ventricular Fibrillation

The following drugs and medications are in some way related to, or used in the treatment of Ventricular Fibrillation. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

Learn more about Ventricular Fibrillation

Medical Encyclopedia:

Ventricular fibrillation

Drug List:

Anestacaine

Cordarone

Cordarone-I-V-Injection

Thursday, 20 September 2012

Hypertensive Heart without CHF and Renal Disease Medications

There are currently no drugs listed for "Hypertensive Heart without CHF and Renal Disease".

Learn more about Hypertensive Heart without CHF and Renal Disease

Medical Encyclopedia:

Anesthesia
Renovascular hypertension

Drug List:

Visine Maximum Redness Relief

Generic Name: tetrahydrozoline ophthalmic (TE tra hye DROZ oh leen)

Brand Names: Altazine, Geneye Extra, Geneyes, Opti-Clear, Optigene 3, Redness Relief, Redness Relief Original, Visine, Visine Maximum Redness Relief, Vision Clear

What is Visine Maximum Redness Relief (tetrahydrozoline ophthalmic)?

Tetrahydrozoline ophthalmic narrows the blood vessels (veins and arteries) in your eyes.

Tetrahydrozoline ophthalmic (for the eyes) is used to relieve redness, burning, irritation, and dryness of the eyes caused by wind, sun, and other minor irritants.

Tetrahydrozoline ophthalmic may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Visine Maximum Redness Relief (tetrahydrozoline ophthalmic)?

Do not use tetrahydrozoline ophthalmic without medical advice if you have glaucoma. Do not use this medication while wearing contact lenses. Tetrahydrozoline ophthalmic may contain a preservative that can discolor soft contact lenses. Wait at least 15 minutes after using tetrahydrozoline ophthalmic before putting your contact lenses in. Do not allow the tip of the dropper to touch any surface, including your eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye. Do not use tetrahydrozoline ophthalmic more often than recommended, or use it for longer than 48 to 72 hours without medical advice. Long-term use of this medication may damage the blood vessels in the eyes. Call your doctor if your symptoms do not improve or if they get worse.

What should I discuss with my healthcare provider before using Visine Maximum Redness Relief (tetrahydrozoline ophthalmic)?

Do not use tetrahydrozoline ophthalmic without medical advice if you have glaucoma.

Ask a doctor or pharmacist if it is safe for you to use this medicine if you have:

heart disease or coronary artery disease;

high blood pressure;

diabetes; or

a thyroid disorder.

FDA pregnancy category C. It is not known whether tetrahydrozoline ophthalmic will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether tetrahydrozoline nasal passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give this medication to a child without a doctor's advice.

How should I use Visine Maximum Redness Relief (tetrahydrozoline ophthalmic)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Do not use tetrahydrozoline ophthalmic more often than recommended, or use it for longer than 48 to 72 hours without medical advice. Long-term use of this medication may damage the blood vessels in the eyes. Call your doctor if your symptoms do not improve or if they get worse. Do not use this medication while you are wearing contact lenses. This medication may contain a preservative that can be absorbed by soft contact lenses. Wait at least 15 minutes after using tetrahydrozoline before putting your contact lenses in. Wash your hands before and after using the eye drops.

To apply the eye drops:

Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the tip down. Look up and away from the dropper as you squeeze out a drop, then close your eye.

Gently press your finger to the inside corner of the eye (near your nose) for about 1 minute to keep the liquid from draining into your tear duct.

Do not allow the dropper tip to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

Do not allow the tip of the dropper to touch any surface, including your eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

Do not use the eye drops if the liquid has changed colors or has particles in it.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Since tetrahydrozoline ophthalmic is used on an as needed basis, you are not likely to miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Visine Maximum Redness Relief (tetrahydrozoline ophthalmic)?

Do not use other eye medications during treatment with tetrahydrozoline ophthalmic unless your doctor tells you to.

Visine Maximum Redness Relief (tetrahydrozoline ophthalmic) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using tetrahydrozoline ophthalmic and call your doctor at once if you have a serious side effect such as:

severe burning, stinging, swelling, or other irritation after using the eye drops;

fast or pounding heartbeats; or

dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Less serious side effects may include:

burning, stinging, pain, or increased redness of the eye;

tearing or blurred vision;

nausea;

nervousness, dizziness, drowsiness;

sleep problems (insomnia); or

headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Visine Maximum Redness Relief (tetrahydrozoline ophthalmic)?

Tell your doctor about all other medicines you use, especially:

an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate); or

a beta blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Dutoprol, Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others.

This list is not complete and other drugs may interact with tetrahydrozoline ophthalmic. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Visine Maximum Redness Relief resources

Visine Maximum Redness Relief Side Effects (in more detail)
Visine Maximum Redness Relief Use in Pregnancy & Breastfeeding
Visine Maximum Redness Relief Drug Interactions
0 Reviews for Visine Maximum Redness Relief - Add your own review/rating

Clarinex Monograph (AHFS DI)

Visine Eye Drops MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Visine Maximum Redness Relief with other medications

Eye Dryness/Redness

Where can I get more information?

Your pharmacist can provide more information about tetrahydrozoline ophthalmic.

See also: Visine Maximum Redness Relief side effects (in more detail)

Sunday, 16 September 2012

carbetapentane, diphenhydramine, and phenylephrine

Generic Name: carbetapentane, diphenhydramine, and phenylephrine (car bay tah PEN tane, die fen HIGH dra meen, and feh nill EH frin)

Brand names: D-Tann CT, Dytan-CS, Uni-Tann CS, Dytan-CD, D-Tann CD

What is carbetapentane, diphenhydramine, and phenylephrine?

Carbetapentane is a cough suppressant.

Diphenhydramine is an antihistamine. It blocks the effects of the naturally occurring chemical histamine in the body. Diphenhydramine prevents sneezing; itchy, watery eyes and nose; and other symptoms of allergies and hay fever.

Phenylephrine is a decongestant. It works by constricting (shrinking) blood vessels (veins and arteries) in the body. Constriction of blood vessels in the sinuses and nose decreases congestion.

Carbetapentane, diphenhydramine, and phenylephrine is used to treat cough and nasal congestion associated with allergies or the common cold.

Carbetapentane, diphenhydramine, and phenylephrine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about carbetapentane, diphenhydramine, and phenylephrine?

Use caution when driving, operating machinery, or performing other hazardous activities. Carbetapentane, diphenhydramine, and phenylephrine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking carbetapentane, diphenhydramine, and phenylephrine.

What should I discuss with my healthcare provider before taking carbetapentane, diphenhydramine, and phenylephrine?

Do not take carbetapentane, diphenhydramine, and phenylephrine if you have taken selegiline (Carbex, Eldepryl) or a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Before taking this medication, tell your doctor if you have

epilepsy or another seizure disorder;

been diagnosed with sleep apnea (periods of not breathing during sleep);

thyroid problems;

asthma, emphysema, or chronic obstructive pulmonary disease (COPD);

gallbladder disease;

a head injury;

Addison's disease;

diabetes;

glaucoma;

an ulcer or an obstruction in the stomach;

bladder problems or difficulty urinating;

an enlarged prostate;

high blood pressure, irregular heartbeats, or any type of heart disease;

kidney problems; or

liver problems.

You may not be able to take carbetapentane, diphenhydramine, and phenylephrine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

It is not known whether this medication will be harmful to an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. Carbetapentane, diphenhydramine, and phenylephrine may pass into breast milk and be harmful to a nursing baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby. If you are over 65 years of age, you may be more likely to experience side effects from carbetapentane, diphenhydramine, and phenylephrine. You may need a lower dose of this medication.

How should I take carbetapentane, diphenhydramine, and phenylephrine?

Take carbetapentane, diphenhydramine, and phenylephrine exactly as directed. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Shake the suspension well before measuring a dose. To ensure that you get a correct dose, measure the liquid form of carbetapentane, diphenhydramine, and phenylephrine with a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Do not take more of this medication than is recommended. An overdose of this medication can cause serious harm.

Do not take carbetapentane, diphenhydramine, and phenylephrine for longer than is prescribed. If your symptoms do not improve, if they get worse, or if they are accompanied by fever, talk to your doctor.

Store carbetapentane, diphenhydramine, and phenylephrine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention if an overdose is suspected.

Symptoms of a carbetapentane, diphenhydramine, and phenylephrine overdose include dryness of the mouth, large pupils, flushing, nausea, vomiting, hyperactivity, or hallucinations.

What should I avoid while taking carbetapentane, diphenhydramine, and phenylephrine?

Do not take other over-the-counter cough, cold, allergy, diet, or sleep aids while taking carbetapentane, diphenhydramine, and phenylephrine without first talking to your doctor or pharmacist. Other medications may also contain carbetapentane, phenylephrine, pyrilamine or other similar drugs. You may accidentally take too much of these medicines.

Carbetapentane, diphenhydramine, and phenylephrine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, other antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if carbetapentane, diphenhydramine, and phenylephrine is taken with any of these medications.

Carbetapentane, diphenhydramine, and phenylephrine side effects

Serious side effects are unlikely to occur. Stop taking carbetapentane, diphenhydramine, and phenylephrine and seek emergency medical attention if an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives) is experienced.

Other, less serious side effects may be more likely to occur. Continue to take carbetapentane, diphenhydramine, and phenylephrine and talk to your doctor or try another similar medication if you experience

dryness of the eyes, nose, or mouth;

drowsiness or dizziness;

blurred vision;

difficulty urinating; or

excitation in children.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Carbetapentane, diphenhydramine, and phenylephrine Dosing Information

Usual Adult Dose for Allergic Rhinitis:

carbetapentane/diphenhydramine/phenylephrine 30 mg-25 mg-7.5 mg/5 ml oral suspension, extended release:
carbetapentane/diphenhydramine/phenylephrine 30 mg-25 mg-15 mg/5 ml oral suspension, extended release
5 to 10 mL orally every 12 hours.

carbetapentane/diphenhydramine/phenylephrine 30 mg-25 mg-10 mg oral tablet, extended release and chewable, extended release:
1 to 2 tablets orally every 12 hours.

Usual Adult Dose for Cold Symptoms:

Usual Adult Dose for Cough and Nasal Congestion:

Usual Pediatric Dose for Allergic Rhinitis:

carbetapentane/diphenhydramine/phenylephrine 30 mg-25 mg-7.5 mg/5 mL oral suspension, extended release:
carbetapentane/diphenhydramine/phenylephrine 30 mg-25 mg-15 mg/5 ml oral suspension, extended release:
2 years to 6 years to >=12 years: 5 to 10 mL orally every 12 hours.

carbetapentane/diphenhydramine/phenylephrine 30 mg-25 mg-15 mg/5 ml oral suspension, extended release

carbetapentane/diphenhydramine/phenylephrine 30 mg-25 mg-10 mg oral tablet, extended release and chewable, extended release:
6 years to >=12 years 1 to 2 tablets orally every 12 hours.

Usual Pediatric Dose for Cold Symptoms:

Usual Pediatric Dose for Cough and Nasal Congestion:

What other drugs will affect carbetapentane, diphenhydramine, and phenylephrine?

Drugs other than those listed here may also interact with carbetapentane, diphenhydramine, and phenylephrine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

More carbetapentane, diphenhydramine, and phenylephrine resources

Carbetapentane, diphenhydramine, and phenylephrine Side Effects (in more detail)
Carbetapentane, diphenhydramine, and phenylephrine Use in Pregnancy & Breastfeeding
Carbetapentane, diphenhydramine, and phenylephrine Drug Interactions
Carbetapentane, diphenhydramine, and phenylephrine Support Group
1 Review for Carbetapentane, diphenhydramine, and phenylephrine - Add your own review/rating

Compare carbetapentane, diphenhydramine, and phenylephrine with other medications

Cold Symptoms
Cough and Nasal Congestion
Hay Fever

Where can I get more information?

Your pharmacist has additional information about carbetapentane, diphenhydramine, and phenylephrine written for health professionals that you may read.

See also: carbetapentane, diphenhydramine, and phenylephrine side effects (in more detail)

Saturday, 15 September 2012

Lecithin Natural

Generic Name: lecithin (LEH sih thin)

Brand Names: Lecithin Natural, Lecithin-Softgels, Soya Lecithin

What is Lecithin Natural (lecithin)?

The use of lecithin in cultural and traditional settings may differ from concepts accepted by current Western medicine. When considering the use of herbal supplements, consultation with a primary health care professional is advisable. Additionally, consultation with a practitioner trained in the uses of herbal/health supplements may be beneficial, and coordination of treatment among all health care providers involved may be advantageous.

Lecithin is also known as lecithol, vitellin, kelecin, and granulestin. Lecithin is a naturally occurring substance found in beef liver, steak, eggs, peanuts, cauliflower, and oranges. Commercial lecithin products usually come from soybeans, egg yolk, or brain tissue.

Lecithin has been used in the treatment and/or prevention of high cholesterol levels, neurologic disorders, and liver ailments.

Lecithin has not been evaluated by the FDA for safety, effectiveness, or purity. All potential risks and/or advantages of lecithin may not be known. Additionally, there are no regulated manufacturing standards in place for these compounds. There have been instances where herbal/health supplements have been sold which were contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Lecithin may also have uses other than those listed in this product guide.

What is the most important information I should know about Lecithin Natural (lecithin)?

Who should not take Lecithin Natural (lecithin)?

Talk to your doctor before taking lecithin if you have any other medical conditions, allergies, or if you take other medicines or herbal/health supplements. Lecithin may not be recommended in some situations.

Do not take lecithin without first talking to your doctor if you are pregnant or could become pregnant. Lecithin is generally not recommended for use during pregnancy. Do not take lecithin without first talking to your doctor if you are breast-feeding a baby. There is no information available regarding the use of lecithin by children. Do not give any herbal/health supplement to a child without first talking to the child's doctor.

How should I take Lecithin Natural (lecithin)?

If you choose to use lecithin, use it as directed on the package or as directed by your doctor, pharmacist, or other health care provider.

Standardized extracts, tinctures, and solid formulations of herbal/health supplements may provide a more reliable dose of the product.

Lecithin is available in pill, granule, paste, and liquid formulations. Other formulations may also be available.

Do not take more of this product than is directed. Do not use different formulations (e.g., tablets, liquid, and others) of lecithin at the same time, unless specifically directed to do so by a health care professional. Using different formulations together increases the risk of an overdose of lecithin.

Store lecithin as directed on the package. In general, lecithin should be protected from light and moisture.

What happens if I miss a dose?

No information is available regarding a missed dose of lecithin. Consult your doctor, pharmacist, or health care provider if you require further information.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a lecithin overdose are not known.

What should I avoid while taking Lecithin Natural (lecithin)?

There are no known restrictions on food, beverages, or activity while taking lecithin, unless otherwise directed by your health care provider.

Lecithin Natural (lecithin) side effects

Although uncommon, allergic reactions to lecithin have been reported. Stop taking lecithin and seek emergency medical attention if you experience symptoms of a serious allergic reaction including difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives.

Other less serious side effects have also been infrequently reported. Talk to your doctor or pharmacist if you experience

decreased appetite,

nausea, or

increased salivation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Lecithin Natural (lecithin)?

There are no reported interactions between lecithin and other medications. Talk to your doctor, pharmacist, or health care provider before taking any prescription or over-the-counter medicines or other herbal/health supplements.

More Lecithin Natural resources

Lecithin Natural Support Group
0 Reviews for Lecithin Natural - Add your own review/rating

Lecithin Natural MedFacts for Professionals (Wolters Kluwer)

Lecithin Natural MedFacts for Consumers (Wolters Kluwer)

Lecithin

Compare Lecithin Natural with other medications

Herbal Supplementation

Where can I get more information?

Your doctor, pharmacist, or health care provider may have more information about lecithin.

Friday, 14 September 2012

Autoplex T

Generic Name: anti-inhibitor coagulant complex (an TEE in HIB i tor koe AG yoo lant KOM plex)

Brand Names: Autoplex T, Feiba NF, Feiba VH Immuno

What is Autoplex T (anti-inhibitor coagulant complex)?

Anti-inhibitor coagulant complex is made from proteins normally found in human blood that allow the blood to clot.

Anti-inhibitor coagulant complex is used to treat or prevent bleeding in people with hemophilia A or B and Factor VIII inhibitors.

Anti-inhibitor coagulant complex may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Autoplex T (anti-inhibitor coagulant complex)?

You should not use anti-inhibitor coagulant complex if you are allergic to it.

Before using this medication, tell your doctor if you have coronary artery disease or a history of heart attack, stroke, or blood clot.

Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

Anti-inhibitor coagulant complex is made from human plasma (part of the blood) which may contain viruses and other infectious agents. Donated plasma is tested and treated to reduce the risk of it containing infectious agents, but there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using this medication.

Wear a medical alert tag or carry an ID card stating that you have hemophilia. Any medical care provider who treats you should know that you have a bleeding or blood clotting disorder.

What should I discuss with my healthcare provider before using Autoplex T (anti-inhibitor coagulant complex)?

You should not use anti-inhibitor coagulant complex if you are allergic to it.

To make sure you can safely use anti-inhibitor coagulant complex, tell your doctor if you have any of these other conditions:

coronary artery disease; or

history of heart attack, stroke, or blood clot.

FDA pregnancy category C. It is not known whether anti-inhibitor coagulant complex will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether anti-inhibitor coagulant complex passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use Autoplex T (anti-inhibitor coagulant complex)?

Anti-inhibitor coagulant complex is injected into a vein through an IV. You may be shown how to use an IV at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

Anti-inhibitor coagulant complex is usually given once every 6 to 12 hours until your condition improves.

Anti-inhibitor coagulant complex is a powder medicine that must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medication.

Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Wear a medical alert tag or carry an ID card stating that you have hemophilia. Any medical care provider who treats you should know that you have a bleeding or blood clotting disorder. Store anti-inhibitor coagulant complex in a refrigerator. Do not freeze. Take the vial out of the refrigerator and allow it to reach room temperature before mixing with the diluent. Do not heat the medicine. You may store this medicine at room temperature for up to 6 months or until the expiration date on the label. After mixing anti-inhibitor coagulant complex with the diluent, store the mixture at room temperature and use it within 3 hours. Do not refrigerate mixed medicine.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of anti-inhibitor coagulant complex.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include some of the serious side effects listed in this medication guide.

What should I avoid while using Autoplex T (anti-inhibitor coagulant complex)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Autoplex T (anti-inhibitor coagulant complex) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), feeling like you might pass out;

fever, chills, runny nose, and drowsiness, followed by rash and joint pain about 2 weeks later;

sudden numbness or weakness, especially on one side of the body;

sudden severe headache, confusion, problems with vision, speech, or balance;

pain, swelling, warmth, or redness in one or both legs;

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

fast or slow heart rate, weak pulse, trouble breathing, chest pain or cough; or

nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

pain around the IV needle or

numbness or tingling, especially in your face.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Autoplex T (anti-inhibitor coagulant complex)?

The following drugs should not be given within 12 hours after you receive anti-inhibitor coagulant complex.

aminocaproic acid (Amicar);

desmopressin (DDAVP); or

tranexamic acid (Cyklokapron, Lysteda).

This list is not complete and other drugs may interact with anti-inhibitor coagulant complex. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Autoplex T resources

Autoplex T Use in Pregnancy & Breastfeeding
Autoplex T Drug Interactions
Autoplex T Support Group
0 Reviews for Autoplex T - Add your own review/rating

Autoplex T Advanced Consumer (Micromedex) - Includes Dosage Information

Anti-Inhibitor Coagulant Complex Professional Patient Advice (Wolters Kluwer)

Anti-inhibitor Coagulant Complex Monograph (AHFS DI)

Anti-Inhibitor Coagulant Complex MedFacts Consumer Leaflet (Wolters Kluwer)

FEIBA NF Prescribing Information (FDA)

Compare Autoplex T with other medications

Hemophilia A

Where can I get more information?

Your doctor or pharmacist can provide more information about anti-inhibitor coagulant complex.

Monday, 10 September 2012

Anusol Ointment

1. Name Of The Medicinal Product

Anusol Ointment

2. Qualitative And Quantitative Composition

Each 100g ointment contains:

Zinc Oxide 10.75 g

Bismuth Subgallate 2.25 g

Balsam Peru 1.875 g

Bismuth Oxide 0.875 g

3. Pharmaceutical Form

A light buff coloured ointment.

4. Clinical Particulars

4.1 Therapeutic Indications

Symptomatic relief of uncomplicated internal and external haemorrhoids, pruritus ani, proctitis and fissures. Also indicated post operatively in ano-rectal surgical procedures and after incision of thrombosed or sclerosed ano-rectal veins.

Anusol Ointment provides antiseptic, astringent and emollient properties which help to relieve discomfort associated with minor ano-rectal conditions.

4.2 Posology And Method Of Administration

Topical.

Adults and Elderly (over 65 years): Apply to the affected area at night, in the morning and after each evacuation until the condition is controlled. Thoroughly cleanse the affected area, dry and apply ointment. Anusol Ointment should be applied on a gauze dressing. For internal conditions use rectal nozzle provided. Remove the nozzle cap. Clean the nozzle after each use. Not to be taken orally.

Children: Not recommended

4.3 Contraindications

Known hypersensitivity to any of the constituents.

4.4 Special Warnings And Precautions For Use

None known.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

None known.

4.6 Pregnancy And Lactation

Whilst formal studies on the effect of this product during pregnancy have not been conducted, there is no epidemiological evidence of adverse effects either to the pregnant mother or foetus.

4.7 Effects On Ability To Drive And Use Machines

None known.

4.8 Undesirable Effects

Rarely, sensitivity reactions. Patients may occasionally experience transient burning on application, especially if the anoderm is not intact.

4.9 Overdose

Treatment of a large acute overdose should include gastric lavage, purgation with magnesium sulphate and complete bed rest. If necessary, apply oxygen and give general supportive measures.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

Anusol Ointment provides antiseptic, astringent and emollient properties which help to relieve discomfort associated with minor ano-rectal conditions.

Bismuth Oxide is weakly astringent with supposed antiseptic properties and has a protective action on mucous membranes and raw surfaces.

Zinc Oxide is an astringent and mild antiseptic and probably owes its actions to the ability of the zinc ion to precipitate protein but other mechanisms may be involved. Zinc Oxide is also used to absorb skin moisture and decrease friction and discourage growth of certain bacteria.

Balsam Peru has a very mild antiseptic action by virtue of its content of cinnamic and benzoic acids. It is believed to promote the growth of epithelial cells.

5.2 Pharmacokinetic Properties

The active ingredients exert their therapeutic effect without being absorbed into the systemic circulation. These observations are supported by evidence from various studies and reviews.

5.3 Preclinical Safety Data

The active ingredients of Anusol are well known constituents of medicinal products and their safety profile is well documented.

6. Pharmaceutical Particulars

6.1 List Of Excipients

Anusol Ointment contains the following excipients:-

Magnesium stearate

Cocoa butter

Lanolin anhydrous

Castor oil

Kaolin light

Petroleum Jelly White

6.2 Incompatibilities

None known.

6.3 Shelf Life

Not less than 3 years when stored in the original packing.

6.4 Special Precautions For Storage

Do not store above 25° C.

6.5 Nature And Contents Of Container

Externally printed and internally lacquered 25 g aluminium tube with plastic cap. A plastic nozzle with cap is also provided for internal application.

6.6 Special Precautions For Disposal And Other Handling

No special requirements.

Administrative Data

7. Marketing Authorisation Holder

McNeil Products Limited

Foundation Park

Roxborough Way

Maidenhead

Berkshire

SL6 3UG

United Kingdom

8. Marketing Authorisation Number(S)

15513/0042

9. Date Of First Authorisation/Renewal Of The Authorisation

14 March 1997

10. Date Of Revision Of The Text

25 February 2008

Sunday, 9 September 2012

Clobex

Generic Name: clobetasol topical (kloe BAY ta sol)

Brand Names: Clobevate, Clobex, Cormax, Embeline E, Olux, Olux-E, Temovate

What is Clobex (clobetasol topical)?

Clobetasol is a topical (for the skin) steroid. It reduces the actions of chemicals in the body that cause inflammation, redness, and swelling.

Clobetasol topical is used to treat the inflammation and itching caused by a number of skin conditions such as allergic reactions, eczema, and psoriasis.

Clobetasol topical may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Clobex (clobetasol topical)?

Use this medication exactly as directed on the label, or as it has been prescribed by your doctor. Do not use the medication in larger amounts or for longer than recommended. Topical steroid medicine can be absorbed through the skin, which may cause steroid side effects throughout the body.

Do not cover treated skin areas with a bandage or other covering unless your doctor has told you to. If you are treating the diaper area of a baby, do not use plastic pants or tight-fitting diapers. Covering the skin that is treated with clobetasol topical can increase the amount of medicine your skin absorbs, which may lead to unwanted side effects. Follow your doctor's instructions. Do not use this medication on a child without medical advice. Children are more likely to absorb large amounts of a topical steroid through the skin. Steroid absorption in children may cause unwanted side effects, or a delay in growth with long-term use. Talk with your doctor if you think your child is not growing at a normal rate while using this medication over a long treatment period. Contact your doctor if your condition does not improve within 2 weeks of using this medicine, or if you develop signs of a bacterial, fungal, or viral skin infection.

What should I discuss with my healthcare provider before using Clobex (clobetasol topical)?

Do not use this medication if you are allergic to clobetasol.

To make sure you can safely take clobetasol topical, tell your doctor if you are allergic to any drugs, or if you have any type of skin infection.

Also tell your doctor if you have diabetes. Topical steroid medicines absorbed through the skin may increase the glucose (sugar) levels in your blood or urine.

FDA pregnancy category C. It is not known whether clobetasol topical will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether clobetasol topical passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not use this medication on a child without medical advice. Children are more likely to absorb large amounts of a topical steroid through the skin. Steroid absorption in children may cause unwanted side effects, or a delay in growth with long-term use. Talk with your doctor if you think your child is not growing at a normal rate while using this medication over a long treatment period.

How should I use Clobex (clobetasol topical)?

Wash your hands before and after using clobetasol topical, unless you are using the medication to treat the skin on your hands.

Apply a small amount to the affected area and rub it gently into the skin. Do not use this medication over a large area of skin.

If you use this medication long-term, your blood will need to be tested often. Visit your doctor regularly.

Store at room temperature away from moisture and heat. Keep from freezing.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

An overdose of clobetasol is not expected to produce life-threatening symptoms. However, long-term use of high steroid doses can lead to symptoms such as thinning skin, easy bruising, changes in the shape or location of body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.

What should I avoid while using Clobex (clobetasol topical)?

Clobetasol topical should not be used to treat any skin condition your doctor has not prescribed it for.

Avoid using clobetasol topical to treat skin on your face, underarms, or groin area without your doctor's advice. Avoid getting this medication in your eyes. If contact does occur, rinse with water. Do not use clobetasol topical on broken or infected skin. Also avoid using this medication in open wounds.

Clobex (clobetasol topical) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Although the risk of serious side effects is low when clobetasol topical is applied to the skin, you should be aware of side effects that can occur if the medication is absorbed into your bloodstream.

Stop using this medication and call your doctor at once if you have severe irritation of any treated skin, or if you show signs of absorbing clobetasol topical through your skin, such as:

blurred vision, or seeing halos around lights;

mood changes;

sleep problems (insomnia);

weight gain, puffiness in your face; or

muscle weakness, feeling tired.

Less serious side effects may include:

mild skin rash, itching, burning, or redness;

dry or cracking skin;

thinning or softening of your skin;

skin rash or irritation around your mouth;

swollen hair follicles;

temporary hair loss;

spider veins;

changes in color of treated skin;

blisters, pimples, or crusting of treated skin; or

stretch marks.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Clobex (clobetasol topical)?

It is not likely that other drugs you take orally or inject will have an effect on topically applied clobetasol topical. But many drugs can interact with each other. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Clobex resources

Clobex Side Effects (in more detail)
Clobex Use in Pregnancy & Breastfeeding
Clobex Drug Interactions
Clobex Support Group
16 Reviews for Clobex - Add your own review/rating

Clobex Prescribing Information (FDA)

Clobex Lotion MedFacts Consumer Leaflet (Wolters Kluwer)

Clobex Advanced Consumer (Micromedex) - Includes Dosage Information

Cormax Prescribing Information (FDA)

Embeline Cream MedFacts Consumer Leaflet (Wolters Kluwer)

Olux Prescribing Information (FDA)

Olux Foam MedFacts Consumer Leaflet (Wolters Kluwer)

Olux-E Prescribing Information (FDA)

Olux-E Emollient Foam MedFacts Consumer Leaflet (Wolters Kluwer)

Temovate Prescribing Information (FDA)

Compare Clobex with other medications

Atopic Dermatitis
Dermatitis
Lichen Planus
Lichen Sclerosus
Psoriasis

Where can I get more information?

Your pharmacist can provide more information about clobetasol topical.

See also: Clobex side effects (in more detail)

Friday, 7 September 2012

Teruflex Blood Bag System

Generic Name: anticoagulant citrate phosphate dextrose (cpd) and as-5 red cell preservative
TERUFLEX® BLOOD BAG SYSTEM WITH BLOOD SAMPLING ARM® CPD/OPTISOL® SOLUTION Issued 8/96

TERUFLEX® BLOOD BAG SYSTEM With Blood Sampling Arm® CPD/OPTISOL® SOLUTION

Read these instructions carefully before use.

INSTRUCTIONS FOR BLOOD COLLECTION: Use aseptic technique

Materials Needed:

VENOJECT® ll Tube Holder (code P-1316R)

VENOJECT® ll Multi-Sample Luer Adapter (code MN *2000)

VENOJECT® ll Plastic Blood Collection Tubes (or equivalent glass or plastic evacuated blood collection tube)

1. Confirm that all numbered tubing of each blood bag unit contains segment numbers.

2. Make a loose knot in donor tubing below "Y" unless alternate methods are used to seal tubing.

3. Clamp donor tubing.

4. Suspend primary bag as far as possible below the donor's arm.

5. Apply blood pressure cuff or tourniquet to donor's arm. Disinfect site of phlebotomy. If blood pressure cuff is used, inflate cuff to approximately 60 mmHg.

6. Remove needle protector and perform phlebotomy. Remove clamp to permit blood flow into primary bag.

CAUTION Do not touch needle after removing the needle protector.

7. Appropriately secure donor tubing to donor's arm.

8. MIX BLOOD WITH ANTICOAGULANT AT SEVERAL INTERVALS DURING COLLECTION.

9. Collect labeled volume of blood (+/–10%).

10. Tighten knot firmly after collection. Clamp between knot and "Y". Sever donor tubing between the knot and clamp. Alternate methods may be used to seal tubing.

CAUTION Do not use the dielectric tube sealer while the needle is connected to the donor's body.

Anytime before Step #13 below, sever donor tubing between the two seals.

Collect blood samples as follows:

a) Connect VENOJECT II Multi-Sample Luer Adapter to VENOJECT II Tube Holder (Fig. 1).

b) Remove covers and connect multi-sample luer adapter to female luer at end of donor sampling tubing (Fig. 2).

c) Snap CLIKTIP in donor sampling tubing to open blood pathway.

Insert Fig. 1 here

Insert Fig. 2 here

d) Insert blood collection tube (VENOJECT II or equivalent) firmly into VENOJECT II Tube Holder : when full, remove sample tube from holder. Repeat to collect additional samples.

11. Reapply clamp to donor tubing between phlebotomy needle and "Y"; release pressure on donor's arm and remove needle.

CAUTION Discard tubing/phlebotomy needle unit according to institutional procedures.

12. Immediately after collection, invert bag several times to assure blood and anticoagulant are well mixed.

13. Strip blood from the donor tubing into bag, mix well, and allow tubing to refill. Seal on or near X marks on donor tubing to provide numbered aliquots of anticoagulated blood for testing.

14. The time of addition of OPTISOL Solution may vary depending on the processing option selected. Add the solution under one of the following conditions.

a) After removal of plasma from freshly collected blood.

b) Within 8 hours of blood collection if components are prepared.

c) Within 72 hours of collection if blood is refrigerated immediately following collection.

15. Centrifuge the unit to separate red cells from plasma.

16. Snap CLlKTIP (inline closure device) of primary collection bag and transfer plasma into satellite bag. Clamp transfer tubing of satellite bag.

17. Snap CLlKTIP of OPTlSOL Solution bag and drain contents into primary bag containing red blood cells. Seal tubing of primary bag in two places, and cut between seals and separate from satellite bag(s).

NOTE: For TERUFLEX double bags, seal OPTISOL Solution bag tubing in two places and cut between seals. Discard OPTISOL Solution container.

18. Invert the red cell- OPTISOL mixture several times to insure the final AS-5 red cell product is well suspended.

19. Store AS-5 Red Blood Cells between 1-6°C.

20. Infuse AS-5 Red Blood Cells within 42 days of collection.

For further processing, use standard component processing techniques.

To open blister package, peel cover film back four fifths of its length.

After opening, unused bags may be stored for 30 days by returning cover film to original position and sealing with tape to prevent possible loss of moisture.

Insert Fig. 3 here

CAUTIONS

•THE PACKET OF AGELESS CONTAINED IN THIS PACKAGE ABSORBS OXYGEN AND GENERATES HEAT ON REMOVAL AND SHOULD BE HANDLED WITH CARE.

• DISPOSE WITH PACKET IN TRAY.

• DO NOT DISPOSE WITH WASTES CONTAINING VOLATILE OR FLAMMABLE MATERIALS.

• DISCARD AGELESS PACKET WITHOUT OPENING.

TERUMO® TERUMO CORPORATION 44-1, 2-CHOME, HATAGAYA, SHIBUYA-KU, TOKYO, JAPAN

®: Registered Trademark

N-BB-OP-A(SP) 3

Tray/Case Label

TERUFLEX® BLOOD BAG SYSTEM with

BLOOD SAMPLING ARM®

CPD WITH OPTISOL® RED CELL PRESERVATIVE SOLUTION

FOR COLLECTION OF 500mL OF BLOOD

Each unit consists of a collection bag containing 70mL of Anticoagulant

CPD solution, with a satellite bag containing 111mL of OPTlSOL Red

Cell Preservative Solution.

Each 70mL Anticoagulant CPD solution USP contains 1.79g Dextrose

(monohydrate) USP, 1.84g Sodium Citrate (dihydrate) USP, 209mg Citric

Acid (anhydrous) USP, 156mg Monobasic Sodium Phosphate

(monohydrate) USP.

Each 111mL OPTISOL Red Cell Preservative Solution contains 974mg

Sodium Chloride USP, 1.00g Dextrose (monohydrate) USP, 583mg

Mannitol USP, 33.3mg Adenine USP.

STERILE, NON-PYROGENIC FLUID PATH.

DO NOT USE UNLESS ANTICOAGULANT IS CLEAR.

CODE

LOT No.

EXPIRY

UNITS

DONOR NEEDLE 16G x 1 1/2˝ (1.60 x 38mm)

Rx ONLY

RECOMMENDED STORAGE: Room Temperature (15-30°C/59-86°F).

Avoid excessive heat. Protect from freezing.

After opening, unused bags may be stored for 30 days by returning cover film to original

position and sealing with tape to prevent possible loss of moisture.

See Instructions For Blood Collection.

Manufactured by : TERUMO CORPORATION Tokyo, Japan

® : Registered Trademark

Blood Sampling Arm is a trademark of TERUMO CORPORATION.

Rev. 01/03

B-4-H6-A4 2

Place Label here

Teruflex Blood Bag System WITH BLOOD SAMPLING ARM ANTICOAGULANT CITRATE PHOSPHATE DEXTROSE (CPD) AND OPTISOL (AS-5) RED CELL PRESERVATIVE
anticoagulant citrate phosphate dextrose (cpd) and as-5 red cell preservative kit

Product Information
Product Type	HUMAN PRESCRIPTION DRUG	NDC Product Code (Source)	53877-009

Packaging
#	NDC	Package Description	Multilevel Packaging
1	53877-009-41	24 BAG In 1 CASE	contains a BAG
1		1 KIT In 1 BAG	This package is contained within the CASE (53877-009-41)

QUANTITY OF PARTS
Part #	Package Quantity	Total Product Quantity
Part 1	1 BAG	70 mL
Part 2	1 BAG	111 mL

Part 1 of 2

ANTICOAGULANT CITRATE PHOSPHATE DEXTROSE (CPD)
anticoagulant citrate phosphate dextrose (cpd) solution

Product Information

Route of Administration	INTRAVENOUS	DEA Schedule

Active Ingredient/Active Moiety
Ingredient Name	Basis of Strength	Strength
Trisodium Citrate Dihydrate (Citric Acid)	Trisodium Citrate Dihydrate	26.3 g in 1000 mL
Sodium Phosphate, Monobasic (Phosphoric Acid)	Sodium Phosphate, Monobasic	2.22 g in 1000 mL
Dextrose Monohydrate (Dextrose)	Dextrose Monohydrate	25.5 g in 1000 mL
Anhydrous Citric Acid (Citric Acid)	Anhydrous Citric Acid	2.99 g in 1000 mL

Inactive Ingredients
Ingredient Name	Strength
Water

Product Characteristics
Color		Score
Shape		Size
Flavor		Imprint Code
Contains

Packaging
#	NDC	Package Description	Multilevel Packaging
1		70 mL In 1 BAG	None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
NDA	NDA880217	05/05/2010

Part 2 of 2

OPTISOL RED CELL PRESERVATIVE
as-5 red cell preservative solution

Product Information

Route of Administration	INTRAVENOUS	DEA Schedule

Active Ingredient/Active Moiety
Ingredient Name	Basis of Strength	Strength
Sodium Chloride (SODIUM CATION)	Sodium Chloride	877 mg in 100 mL
Dextrose Monohydrate (Dextrose)	Dextrose Monohydrate	900 mg in 100 mL
Mannitol (Mannitol)	Mannitol	525 mg in 100 mL
Adenine (Adenine)	Adenine	30 mg in 100 mL

Inactive Ingredients
Ingredient Name	Strength
Water

Product Characteristics
Color		Score
Shape		Size
Flavor		Imprint Code
Contains

Packaging
#	NDC	Package Description	Multilevel Packaging
1		111 mL In 1 BAG	None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
NDA	NDA880217	05/05/2010

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
NDA	NDA880217	05/05/2010

Labeler - Terumo Corporation (690543319)

Establishment
Name	Address	ID/FEI	Operations
Terumo Corp. - Fujinomiya Factory		695214015	manufacture

Revised: 06/2011Terumo Corporation