Rozerem

Generic Name: ramelteon (ram EL tee on)

Brand Names: Rozerem

What is ramelteon?

Ramelteon is a sedative, also called a hypnotic. It works by affecting certain substances in your body that help regulate your "sleep-wake cycle."

Ramelteon is used to treat insomnia that is associated with having trouble falling asleep.

Unlike some other sleep medications, ramelteon is not known to be habit-forming.

Ramelteon may also be used for purposes not listed in this medication guide.

What is the most important information I should know about ramelteon?

You should not use this medication if you are allergic to ramelteon, or if you have severe liver disease.

You should not take ramelteon if you are also taking the antidepressant fluvoxamine (Luvox).

Before taking ramelteon, tell your doctor if you have liver disease, sleep apnea, a breathing disorder such as chronic obstructive pulmonary disease, or a history of depression, mental illness, or suicidal thoughts.

Take ramelteon 30 minutes before your normal bedtime. After you take ramelteon, avoid doing anything other than getting ready for bed.

Avoid taking ramelteon together with or just after eating a high-fat meal. This will make it harder for your body to absorb the medication.

Some people using this medicine have engaged in activity such as driving, eating, or making phone calls and later having no memory of the activity. If this happens to you, stop taking ramelteon and talk with your doctor about another treatment for your sleep disorder.

What should I discuss with my healthcare provider before taking ramelteon?

You should not use this medication if you are allergic to ramelteon, or if you have severe liver disease.

You should not take ramelteon if you are also taking the antidepressant fluvoxamine (Luvox).

To make sure you can safely take ramelteon, tell your doctor if you have any of these other conditions:

• liver disease;


• 
  

  sleep apnea (breathing stops while you are asleep);

  
  


• 
  

  a breathing disorder such as chronic obstructive pulmonary disease (COPD); or

  
  


• 
  

  a history of depression, mental illness, or suicidal thoughts.

  
  

FDA pregnancy category C. It is not known whether ramelteon will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether ramelteon passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Ramelteon may affect the levels of male or female hormones (testosterone or prolactin). This may affect menstrual periods in women, sexual desire in men, or fertility (ability to have children) in either a man or a woman.

How should I take ramelteon?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take this medication with a full glass of water.

Take ramelteon 30 minutes before your normal bedtime. After you take ramelteon, avoid doing anything other than getting ready for bed.

Do not crush, chew, or break the tablet. Swallow it whole.

Avoid taking ramelteon together with or just after eating a high-fat meal. This will make it harder for your body to absorb the medication.

Talk with your doctor if your insomnia does not improve after 7 days of using ramelteon. You may need to be checked for other medical illnesses that may cause insomnia.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

See also: Rozerem dosage (in more detail)

What happens if I miss a dose?

Since ramelteon is usually taken as needed, you may not be on a dosing schedule. Ramelteon should be taken only within 30 minutes of your normal bedtime. Do not take extra medicine to make up a missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking ramelteon?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase certain side effects of ramelteon.

Ramelteon side effects

Some people using this medicine have engaged in activity such as driving, eating, or making phone calls and later having no memory of the activity. If this happens to you, stop taking ramelteon and talk with your doctor about another treatment for your sleep disorder. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking ramelteon and call your doctor at once if you have a serious side effect such as:

• 
  

  unusual thoughts or behavior, hallucinations, worsening depression, thoughts about hurting yourself;

  
  


• 
  

  a missed menstrual period;

  
  


• 
  

  nipple discharge; or

  
  


• 
  

  loss of interest in sex.

  
  

Less serious side effects may include:

• 
  

  drowsiness, tired feeling;

  
  


• 
  

  dizziness;

  
  


• 
  

  nausea; or

  
  


• 
  

  worsening sleep problems.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect ramelteon?

Tell your doctor about all other medicines you use, especially:

• 
  

  donepezil (Aricept);

  
  


• 
  

  doxepin (Sinequan, Silenor);

  
  


• 
  

  methoxsalen (Oxsoralen);

  
  


• 
  

  primaquine or thiabendazole (Mintezol);

  
  


• 
  

  rifampin (Rifadin, Rifater, Rifamate, Rimactane);

  
  


• 
  

  an antibiotic such as ciprofloxacin (Cipro), norfloxacin (Noroxin), or ofloxacin (Floxin);

  
  


• 
  

  heart rhythm medication such as amiodarone (Cordarone, Pacerone) or mexiletine (Mexitil); or

  
  


• 
  

  an antifungal medication such as fluconazole (Diflucan) or ketoconazole (Nizoral).

  
  

This list is not complete and other drugs may interact with ramelteon. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Rozerem resources

• Rozerem Side Effects (in more detail)
• Rozerem Dosage
• Rozerem Use in Pregnancy & Breastfeeding
• Drug Images
• Rozerem Drug Interactions
• Rozerem Support Group
• 27 Reviews for Rozerem - Add your own review/rating

• Rozerem Prescribing Information (FDA)


• Rozerem Monograph (AHFS DI)


• Rozerem Advanced Consumer (Micromedex) - Includes Dosage Information


• Rozerem Consumer Overview


• Rozerem MedFacts Consumer Leaflet (Wolters Kluwer)


• Ramelteon Professional Patient Advice (Wolters Kluwer)

Compare Rozerem with other medications

• Insomnia

Where can I get more information?

• Your pharmacist can provide more information about ramelteon.

See also: Rozerem side effects (in more detail)

Soludrill Expectorant

Soludrill Expectorant may be available in the countries listed below.

Ingredient matches for Soludrill Expectorant

Carbocisteine

Carbocisteine is reported as an ingredient of Soludrill Expectorant in the following countries:

• Luxembourg

International Drug Name Search

Solvipect

Solvipect may be available in the countries listed below.

Ingredient matches for Solvipect

Guaifenesin

Guaifenesin is reported as an ingredient of Solvipect in the following countries:

• Norway

International Drug Name Search

Dexium Injection

Generic Name: dexamethasone injection

Dosage Form: FOR ANIMAL USE ONLY

CAUTION:  Federal law restricts this drug to use by or on the order of a licensed veterinarian.

DESCRIPTION:  Dexamethasone Solution is a synthetic analogue of prednisolone, having similar but more potent anti-inflammatory therapeutic action and diversified hormonal and metabolic effects.  Modification of the basic corticoid structure as achieved in Dexium offers enhanced anti-inflammatory effect compared to older corticosteroids.  The dosage of Dexium required is markedly lower than that of prednisone and prednisolone.  Dexium is not species-specific; however, the veterinarian should read the sections on INDICATIONS, DOSAGE, SIDE EFFECTS, CONTRAINDICATIONS, PRECAUTIONS, and WARNINGS before this drug is used.  Dexium is intended for intravenous or intramuscular administration.  Each mL contains 2 mg dexamethasone, 500 mg polyethylene glycol 400, 9 mg benzyl alcohol, 1.8 mg methylparaben and 0.2 mg propylparaben as preservatives, 4.75% alcohol, HCl to adjust pH to approximately 4.9, water for injection q.s.

EXPERIMENTAL STUDIES:  Experimental animal studies on dexamethasone have revealed it possesses greater anti-inflammatory activity than many steroids.  Veterinary clinical evidence indicates dexamethasone has approximately 20 times the anti-inflammatory activity of prednisolone and 70 to 80 times that of hydrocortisone.  Thymus involution studies show dexamethasone possesses 25 times the activity of prenisolone.  In reference to mineralcorticoid activity, dexamethasone does not caused significant sodium or water retention.  Metabolic balance studies show that animals on controlled and limited protein intake will exhibit nitrogen losses on exceedingly high dosages.

INDICATIONS:  Dexium is indicated for the treatment of primary bovine ketosis and as an anti-inflammatory agent in the bovine and equine.  As supportive therapy, Dexium may be used in the management of various rheumatic, allergic, dermatologic, and other diseases known to be responsive to anti-inflammatory corticosteroids.  Dexium may be used intravenously as supportive therapy when an immediate hormonal response is required.

Bovine Ketosis:  Dexium is offered for the treatment of primary ketosis.  The gluconeogenic effects of Dexium, when administered intramuscularly, are generally noted within the first 6 to 12 hours.  When Dexium is used intravenously, the effects may be noted sooner.  Blood sugar levels rise to normal levels rapidly and generally rise to above normal levels within 12 to 24 hours.  Acetone bodies are reduced to normal concentrations usually within 24 hours.  The physical attitude of animals treated with Dexium brightens and appetite improves, usually within 12 hours.  Milk production, which is suppressed as a compensatory reaction in this condition, begins to increase.  In some instances, it may even surpass previous peaks.  The recovery process usually takes from 3 to 7 days.

Supportive Therapy:  Dexium may be used as supportive therapy in mastitis, metritis, traumatic gastritis, and pyelonephritis, while appropriate primary therapy is administered.  In these cases, the corticosteroid combats accompanying stress and enhances the feeling of general well-being.  Dexium may also be used as supportive therapy in inflammatory conditions such as arthritic conditions, snake bite, acute mastitis, shipping fever, pneumonia, laminitis, and retained placenta.

Equine:  Dexium is indicated for the treatment of acute musculoskeletal inflammations, such as bursitis, carpitis, osselets, tendonitis, myositis, and sprains.  If boney changes exist in any of these conditions, joints or accessory structures, a response to Dexium cannot be expected.  In addition, Dexium may be used as supportive therapy in fatigue, heat exhaustion, influenza, laminitis, and retained placenta provided that the primary cause is determined and corrected.

ADMINISTRATION AND DOSAGE:  Therapy with Dexium, as with any other potent corticosteroid, should be individualized according to the severity of the condition being treated, anticipated duration of steroid therapy, and animals threshold or tolerance for steroid excess.  Treatment may be changed over to Dexium from any other glucocorticoid with proper reduction or adjustment of doage.

Bovine:  Dexium: 5 - 20 mg intravenously or intramuscularly.

Equine:  Dexium: 2.5 - 5 mg intravenously or intramuscularly.

CONTRAINDICATIONS:  Except for emergency therapy, do not use in animals with chronic nephritis and hyper-corticalism (Cushings syndrome).  Existence of congestive heart failure, diabetes, and osteoporosis are relative contraindications.  Do not use in viral infections during with viremic stage.

PRECAUTIONS:  Animals receiving Dexium should be under close observation.  Because of the anti-inflammatory action of corticosteroids, signs of infection may be masked and it may be necessary to stop treatment until a further diagnosis is made.  Overdosage of some glucocorticoids may result in sodium retention, fluid retention, potassium loss, and weight gain.

Dexium may be administered to animals with acute or chronic bacterial infections providing the infections are controlled with appropriate antibiotic or chemotherapeutic agents.

Doses greater than those recommended in horses may produce transient drowsiness or lethargy in some horses.  The lethargy usually abates in 24 hours.  Use of corticosteroids, depending on the dose, duration, and specified steroid, may result in inhibition of endogenous steroid production following drug withdrawal.  In patients presently receiving or recently withdrawn from systemic corticosteroid treatments, therapy with a rapidly acting corticosteroid should be considered in unusually stressful situations.

WARNINGS:  Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis.

Additionally, corticosteroids administered to dogs, rabbits, and rodents, during pregnancy have produced cleft palate.  Other congenital anomalies including deformed forelegs, phocomelia, and anasarca have been reported in offspring of dogs which received corticosteroids during pregnancy.

A withdrawal period has not been established for this product in pre-ruminating calves.  Do not use in calves to be processed for veal.

SIDE EFFECTS:  Side effects, such as SAP and SGPT enzyme elevations, weight loss, anorexia, polydipsia, and polyuria, have occurred following corticosteroids in dogs.  Vomiting and diarrhea (occassionally bloody) have been observed in cats and dogs.  Cushing's syndrome in dogs has been reported in association with prolonged or repeated steroid therapy.  Corticosteroids reportedly cause laminitis in horses.

HOW SUPPLIED:  Dexium, 2 mg per mL, 100 mL multiple dose vial.

STORAGE:  Store between 2 degrees and 30 degrees C (36 degrees and 86 degrees F).

Dexium

Dexamethasone Solution

Veterinary 2 mg per mL Sterile

CAUTION:  Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.

ANADA #200-312, Approved by FDA

Net Contents:  100 mL

DEXIUM  dexamethasone  injection, solution

Product Information Product Type PRESCRIPTION ANIMAL DRUG NDC Product Code (Source) 61133-0899 Route of Administration INTRAMUSCULAR, INTRAVENOUS DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength Dexamethasone (Dexamethasone) Dexamethasone 2 mg  in 1 mL

Inactive Ingredients Ingredient Name Strength Propylparaben

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 61133-0899-9 100 mL In 1 VIAL, MULTI-DOSE None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
ANADA	ANADA200312	10/20/2003

Labeler - Bimeda, Inc. Division of Cross Vetpharm Group (043653216)

Registrant - Bimeda, Inc. Division of Cross Vetpharm Group (043653216)

Establishment
Name	Address	ID/FEI	Operations
Bimeda-MTC Animal Health, Division of Cross Vetpharm Group		256232216	manufacture

Revised: 12/2010Bimeda, Inc. Division of Cross Vetpharm Group

Fungipan

Fungipan may be available in the countries listed below.

Ingredient matches for Fungipan

Ketoconazole

Ketoconazole is reported as an ingredient of Fungipan in the following countries:

• Oman

International Drug Name Search

Somalgyl

Somalgyl may be available in the countries listed below.

Ingredient matches for Somalgyl

Metamizole

Metamizole magnesium (a derivative of Metamizole) is reported as an ingredient of Somalgyl in the following countries:

• Belize


• El Salvador

International Drug Name Search

Rolan

Rolan may be available in the countries listed below.

Ingredient matches for Rolan

Mefenamic Acid

Mefenamic Acid is reported as an ingredient of Rolan in the following countries:

• Turkey

Ranitidine

Ranitidine is reported as an ingredient of Rolan in the following countries:

• Oman


• Tunisia

International Drug Name Search

Mequitazina

Mequitazina may be available in the countries listed below.

Ingredient matches for Mequitazina

Mequitazine

Mequitazina (DCIT) is also known as Mequitazine (Rec.INN)

International Drug Name Search

Glossary

DCIT	Denominazione Comune Italiana
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)

Click for further information on drug naming conventions and International Nonproprietary Names.

Paracetamol Hänseler

Paracetamol Hänseler may be available in the countries listed below.

Ingredient matches for Paracetamol Hänseler

Paracetamol

Paracetamol is reported as an ingredient of Paracetamol Hänseler in the following countries:

• Switzerland

International Drug Name Search

Benzoyl Peroxide Wash

Pronunciation: BEN-zoyl per-OX-ide
Generic Name: Benzoyl Peroxide
Brand Name: Examples include Benzac AC and EthexDERM BPW

Benzoyl Peroxide Wash is used for:

Treating acne.

Benzoyl Peroxide Wash is a keratolytic agent with antibacterial actions. The effectiveness of benzoyl peroxide appears to be due to its antibacterial, peeling (keratolytic), and drying actions.

Do NOT use Benzoyl Peroxide Wash if:

• you are allergic to any ingredient in Benzoyl Peroxide Wash

Contact your doctor or health care provider right away if any of these apply to you.

Before using Benzoyl Peroxide Wash:

Some medical conditions may interact with Benzoyl Peroxide Wash. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with Benzoyl Peroxide Wash. However, no specific interactions with Benzoyl Peroxide Wash are known at this time.

Ask your health care provider if Benzoyl Peroxide Wash may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Benzoyl Peroxide Wash:

Use Benzoyl Peroxide Wash as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Wet the affected area. Use your hands to apply the medicine and gently wash the affected area. Rinse with water and pat dry.


• Wash your hands after using Benzoyl Peroxide Wash.


• If you miss a dose of Benzoyl Peroxide Wash, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Benzoyl Peroxide Wash.

Important safety information:

• Use on the skin only. Avoid getting Benzoyl Peroxide Wash in your eyes, eyelids, on the inside of your nose or mouth, on highly inflamed or damaged skin, or on your lips. If you get Benzoyl Peroxide Wash in your eyes, immediately wash them out with cool tap water.


• Avoid applying Benzoyl Peroxide Wash to raw or irritated skin, including sunburns, or to open wounds.


• Several weeks may pass before you see improvement in your acne. Continue to use Benzoyl Peroxide Wash for the full time recommended by your doctor. If your acne does not improve or if it gets worse, check with your doctor.


• Talk with your doctor before you use any other medicines, special cleansers, aftershave, or cosmetics on your skin.


• Benzoyl Peroxide Wash may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Benzoyl Peroxide Wash. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.


• Benzoyl Peroxide Wash may cause bleaching. Avoid contact with hair, fabrics, or carpeting.


• Benzoyl Peroxide Wash should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: It is not known if Benzoyl Peroxide Wash can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Benzoyl Peroxide Wash while you are pregnant. It is not known if Benzoyl Peroxide Wash is found in breast milk. If you are or will be breast-feeding while you use Benzoyl Peroxide Wash, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Benzoyl Peroxide Wash:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dryness; feeling of warmth; irritation; itching; peeling; redness; stinging.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; dizziness; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); excessive burning, itching, irritation, peeling, redness, or tenderness of your skin; extreme dryness; swelling.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Benzoyl Peroxide side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include excessive scaling; flushing; redness; swelling.

Proper storage of Benzoyl Peroxide Wash:

Store at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store in a tightly closed container, away from fire, flame, heat, moisture, and light. Keep Benzoyl Peroxide Wash out of the reach of children and away from pets.

General information:

• If you have any questions about Benzoyl Peroxide Wash, please talk with your doctor, pharmacist, or other health care provider.


• Benzoyl Peroxide Wash is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Benzoyl Peroxide Wash. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Benzoyl Peroxide resources

• Benzoyl Peroxide Side Effects (in more detail)
• Benzoyl Peroxide Use in Pregnancy & Breastfeeding
• Benzoyl Peroxide Drug Interactions
• Benzoyl Peroxide Support Group
• 15 Reviews for Benzoyl Peroxide - Add your own review/rating

Compare Benzoyl Peroxide with other medications

• Acne
• Perioral Dermatitis

Natecal

Natecal may be available in the countries listed below.

Ingredient matches for Natecal

Calcium Carbonate

Calcium Carbonate is reported as an ingredient of Natecal in the following countries:

• Chile


• Georgia


• Spain

International Drug Name Search

Streptokinaza

Streptokinaza may be available in the countries listed below.

Ingredient matches for Streptokinaza

Streptokinase

Streptokinase is reported as an ingredient of Streptokinaza in the following countries:

• Poland

International Drug Name Search